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Celpure Diatomite is a High Purity Filter Aid

The patented Celpure manufacturing process is a major advance in filter aid technology. This process produces a media that surpasses conventional diatomite filter aids in purity, performance, regulatory support, and finished product consistency.

Celpure is the ideal choice when developing new high purity processes with diatomite filter aid, and is available in USP-NF Grade and Food Grade.

Studies show that after replacing conventional diatomite filter aids with Celpure diatomite filter aids, extractable impurities are significantly reduced (Table 1).

Extractables Expressed as mg/kg of Filter Aid
  Celite Standard
Super-Cel®
(Food grade)
Celpure® 300
(High Purity grade)
Al 84.1

nd*

Ca 52.5 nd
Mg 50.5 6.2
Fe 20.0 2.8
Zn 10.5 nd
Cu 0.8 0.6
Sb 0.6 nd
Mn 0.7 0.2
Cr 0.2 nd
*(nd) Below detectable limit

Table 1. Extractable analysis by ICP-MS except for Fe (colorimetric complex with 1,10-phenanthroline). Extractables expressed as mg/kg of filter aid extracted from 2-g samples incubated in 100-mL solutions. Solution: 10 mg/mL albumin, 50 mM sodium acetate, pH 4.3. Incubation: 4 h, 160 rpm, 50°C.

Our USP-NF Grade Celpure media was developed as a pharmaceutical CGMP alternative to Food Grade diatomite filter aids. Celpure media addresses the following CGMP needs that are unmet with Food Grade diatomite filter aids:

Regulatory Support
Compendial standards
Purity
Manufacturing and process control
Packaging

For more information on the differences between USP-NF Grade Celpure and Food grades of diatomite see Diatomite Filter Aid in CGMP Parenteral Pharmaceutical Processing: A Regulatory Perspective.

For information on our production facility that serves the pharmaceutical industry, see High Purity Filter Media.

Intended Use of Celpure Media
Celpure media is intended for solid-liquid separation in conjunction with a pressure filtration system. Celpure media is available in a wide range of permeabilities. The least permeable Celpure grades can remove submicron solids in filtration applications (Table 2).

Permeability and Particle Size Retention
Grade Permeability (Darcy) Solids Removed (micron)*
Celpure® 25 0.025 < 0.3
Celpure® 65 0.065 < 0.3
Celpure® 100 0.100 0.4
Celpure® 300 0.300 0.5
Celpure® 1000 1.000 1.5

Table 2.
*Data is provided for comparison purposes only. Depending on the compressibility of the solids, the values may vary by more than an order of magnitude.

Packaging

 

Products- High Purity Filtration, Sorbents, Gas-Liquid Chromatography, Sample Request
Support- Application Notes, SDS - NAFTA, Data Requests, Glossary

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Scanning electron micrograph of Celpure diatom surface (5000x). Celpure media undergoes calcination after purification. This minimizes impurities (illustrated as a clean diatom surface) and allows for a finished product of 96-98% SiO2.

 


Scanning electron micrograph of conventional food grade diatom surface (5000x). Conventional diatomite undergoes calcination without purification. This fuses impurities (illustrated as debris on the surface) into the diatom. Conventional diatomite is typically 86-93% SiO2.

 

 

 
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