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Intended Use

LRA media is intended to be used as a lipid sorbent in the production of biopharmaceuticals. LRA media is also used in sample preparation and solid phase extraction. LRA media provides outstanding performance in terms of lipid capacity, filterability, product recovery, and scalability.

Composition
LRA media is a synthetic calcium silicate hydrate. It is composed of 32% calcium oxide, 48% silicon dioxide, and residual levels of sodium, magnesium, and iron.

Lipid Specificity
The specificity of LRA media for lipids and lipoproteins is high, allowing for removal of contaminating lipids from biological streams without an adverse effect on non-lipids. To demonstrate this, we measured the potential for adsorption of various plasma proteins to LRA media. Following the incubation with cryo-reduced source plasma (samples were mixed for three hours at room temperature) soluble protein was measured by nephelometry. The results show that LRA media is specific for lipids and lipid associated proteins within the normal range of additions. Very little non-specific binding of non-lipid associated proteins was observed (Table 1).

Pressure Flow Curves
LRA media generates acceptable differential pressures at moderately high flux rates (Figure 3). A bed height of 1cm generates differential pressures of 25 psi at a flux rate of 2400 LMH (240 cm/hr linear velocity). When the bed height is increased to 4 cm, the maximum flux rate is 600LMH (60 cm/hr linear velocity) for the same differential pressure. This linear relationship between pressure and bed height must be considered when designing a process using LRA media.

 

Products- High Purity Filtration, Sorbents, Gas-Liquid Chromatography, Sample Request
Support- Application Notes, SDS - NAFTA, Data Requests, Glossary

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